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Activation of the NLRP3 inflammasome increased ROS generation with a loss of mitochondrial membrane potential and mitochondrial integrity in human microglial cells, independent of virus replication

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The most common clinical presentations in lcFAODs are hypoketotic hypoglycemia, cardiomyopathy and myopathy

In addition, the prevalence of CHIP was shown to be higher in the general population in subjects with relatively short LTLs, including males, who are known to have shorter LTLs than females, and elderly, who have shorter LTLs than younger individuals

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