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Aging 15, 1369313709

For example, iron deficiency has been implicated in the pathophysiology of ADHD due to irons essential role as a cofactor of tyrosine hydroxylase in catecholamine synthesis and metabolism, as well as in oxygen transport and brain myelination [14]

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These changes suggest cryotherapy actively modulates immune signaling rather than simply masking symptoms

The overexpression of PGC-1 adeno-associated virus in the brain region of APP23 model mice was observed to result in increased transcription of growth factors, reduced levels of BACE1, and diminished A-mediated neuroinflammation, which collectively led to reduced -amyloid production and neuronal loss (Katsouri et al., 2016)