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Fibroblasts from patients with HGPS show increased levels of basal phosphorylated histone variant H2AX (H2AX) and increased amounts of phosphorylated checkpoint kinase 1 (CHK1) and CHK2, compared with unaffected fibroblasts (Liu Y

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Clinical trials commonly start with 1 mg weekly and gradually increase the dose to higher levels such as 4 mg, 8 mg, or even 12 mg depending on the study protocol

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coagulans being the most studied

Sterilize the site: Use an alcohol swab to clean the chosen area