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Novel nanoparticle-based systems have shown promise for dermal delivery due to their ability to enhance drug permeation across the SC, which is naturally not permeable to a range of substances, as skin acts as a natural physical barrier to particle penetration

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This study enrolled a heterogeneous population of critically ill patients and systematically collected a wide range of clinical data, including disease severity scores, laboratory markers, and ICU outcomes

May explain some observations of systemically administered peptides producing retinal effects despite theoretical barrier restrictions

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