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Bariatric surgery changes the metabolism by changing the composition of the gut microbiota, the way bile acids are broken down, and the release of gut hormones (GLP-1, PYY)[98]

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doi: 10.1007/s40618-017-0718-7 18 Rotondo DottoreGIonniIMenconiFCasiniGSellari-FranceschiniSNardiMet al

The investigation tools should include colorectal transit observations, CT scan, defecography and swallowing studies (81)

Vivani is developing an implantable GLP-1 product candidate designed for reversible 6-12 month dosing with steady PK that may also mitigate tolerability issues

Conversely, a patient with hyperthyroidism might have progressive destruction of the thyroid, or develop blocking antibodies to the TSH-R, and become hypothyroid