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Development and characterization of a melphalan-resistant human multiple myeloma cell line

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To confirm the phenotype changes were driven by OGDHc inhibition, we also treated cells with DM-2OG, mimicking impaired 2-OG metabolism by the OGDHc, and found that, similarly to ML226, DM-2OG increased the CCR7 high CD45RO high population, with a corresponding decrease in the CCR7 low CD45RO high population (Fig

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The recent development of a toolbox for modeling CFE-based genetic circuits will lower the barrier to entry for future researchers