The reasoning is that oral bioavailability is ~4050%, and animal study HED conversions suggest higher doses may be needed for the full effect
I dont own a scale but I can certainly tell my clothes are fitting once again
More isnt automatically better, but in B12s case, bigger doses are usually practical, not performative
Unlike regular sterile water, which requires single-dose use and immediate discarding after opening, bacteriostatic water can safely remain in a vial for extended periods
However, when very high oral doses are taken, approximately 1% can be absorbed through passive diffusion, independent of intrinsic factor, which explains how mega-doses can still raise serum levels
If B12 is given without adequate folate, the methylation cycle can become inefficient