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PMID: 10430080

Journal of Drug Delivery Science and Technology (2020)

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After time and exposure of the skin to many external and internal factors, it loses collagen, as well as more skin defects appear, such as wrinkles, sagging, pigmentation, or traces of acne and scars

However, growing evidence indicates that alternative metabolic routes such as malic enzyme 1 (ME1), isocitrate dehydrogenases (IDH1 and IDH2), and the folate cycle also significantly contribute to NADPH production, particularly under stress conditions or during metabolic reprogramming [43]

Each compound should be reconstituted separately unless experimental design specifies otherwise