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Metabolism of TAM takes place mainly through two main pathways, 4-hydroxylation and N-demethylation, from which TAM is converted to primary metabolites 4-hydroxy-tamoxifen and N-desmethyl-tamoxifen (Klein et al., 2013)

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doi: 10.1016/j.freeradbiomed.2017.02.028 50 JaeschkeH.McGillM