doi: 10.1007/s11154-023-09787-4 48 ZhouRYazdiASMenuPTschoppJ
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It accumulates at high concentrations under hypoxic conditions, inducing A2AR to impair the function and proliferation of T and NK cells, while also stimulating the expression of Foxp3 in Treg cells, leading to immune evasion in cancer and resulting in adverse clinical outcomes (187)
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Additional at-risk groups include: Vegans and strict vegetarians , who may have low dietary B12 intake People with autoimmune conditions , including pernicious anaemia or type 1 diabetes Individuals with gastrointestinal conditions such as Crohn's disease or coeliac disease, which impair nutrient absorption People who have undergone bariatric surgery , which can significantly reduce B12 absorption Long-term users of proton pump inhibitors (PPIs) or H2-receptor antagonists , which reduce gastric acid and impair B12 release from food Those with a family history of either pernicious anaemia or diabetes For these groups, simultaneous monitoring of B12 status and glycaemic markers is particularly important to avoid diagnostic errors
