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Cochrane Database Syst Rev 2018

Vitamin B12 is the most chemically complex of all the vitamins, and cyanocobalamin and hydroxycobalamin are synthetically derived therapeutic forms of vitamin B12.6 Hydroxycobalamin protein binding capacity is greater than that of cyanocobalamin and both of them may cause allergic reactions.6 Vitamin B12 may lead to allergic reactions because of its cobalt molecule, molecular complexity or high molecular mass

Why Is Everyone Talking About Vitamin B12 Injections Right Now

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Research suggests oral B12 supplements (especially sublingual forms) can be just as effective as injections for treating deficiency