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Sequence differences in the VP1VP3 interprotomer cavity between PV and other EVs may explain altered binding orientations and specificities of the benzene sulphonamide derivatives observed in the wt PV2-CP17 complex studied here, compared to other EVs such as CVB3 and CVB4

Methods Cell lines and cell culture The human proximal tubular cell line CD10-135 (referred to as CD10 in the manuscript) [14], originally provided by Prof

Tau (35, 36) and A (37) accumulation induces premature cellular senescence in transgenic mouse models of AD neuropathology