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They bind to different places on the CB1 receptor and as opposed to THC, CBD does not activate the CB1 receptor at all, Klumpers says, with Hill echoing that CBD is not intoxicating and that the two cannabinoids have fundamentally different mechanisms of action. All three academics explicitly reject the broadest takeaway from the Huberman video, which is that sativa and indica varieties of cannabis have markedly different effects elevated and energetic vs