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Cocaine blocks the reuptake of serotonin across the brain, leading to a strong, broad increase in serotonin activity, while alcohol causes more localized, subtle changes in serotonin, as studied by Scripps Research in Serotonin Receptors and Drug Abuse. L ow serotonin levels are especially significant in addictive behaviors related to compulsive, reward-seeking actions, such as binge drinking, gambling, or drug use, where the brains reward system is hijacked to alleviate emotional discomfort or induce a temporary state of well-being

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FDA has now published its position on all 14 substances When the FDA first announced the meeting in April, the agency had not yet published the full briefing package or its proposed position for every substance

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