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If the vial has an unknown history, treat it as unreliable

conservative approach is to avoid co-administration Guideline support / no major guideline addresses this combination Why This Interaction Matters Apixaban is the most prescribed direct oral anticoagulant (DOAC) in the United States, with over 28 million dispensed prescriptions in 2023 according to FDA postmarket data

[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Hu B., Guo H., Zhou P., Shi Z.L

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Geosciences Press, 1995)