(PubMed) Egnell M, Fassier P, Lecuyer L, et al
Lancet Glob Health 5(12):e1221e1234 Das S et al (2022) Innate immunity dysregulation in aging eye and therapeutic interventions
These effects have been demonstrated in both animal studies and human clinical trials for different inflammatory conditions (Cho et al., 2021)
The transcriptional activity, protein expression, and resultant metabolic output of a microbial community can be discordant with its genomic profile due to post-transcriptional regulation, environmental cues, substrate availability, and host-microbe interactions
One main difference between the two is the site of action, where their effects are mostly localized
In snRNA-seq experiments, the variability between mice in one group is masked by pooling of eWAT depots of several mice