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Formononetin upregulates Nrf2/HO-1 signaling and prevents oxidative stress, inflammation, and kidney injury in methotrexate-induced rats

Thus, while we were not successful in obtaining more reactive analogs at this point, this approach allows us to explain the observed low reactivity at physiological pH and offers a valuable tool for guiding the future design of nucleotide-based inhibitors with optimized preorientation and reactivity profiles, providing a systematic framework for enhancing these compounds reactivities in a targeted manner

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Int J Mol Med 28:10651069

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& Rodo, M