Damaged mitochondria generate large amounts of ROS whilst releasing mitochondrial DAMPs to activate PRRs, such as TLR9, thereby participating in inflammation in RA (89)
33 (Suppl 1), S57S70 (2016)
PMID: 40425792 Bone Res Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-B signaling to recruit macrophages and activate the NLRP3 inflammasome
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