The NRF2 signaling pathway, essential for maintaining vascular redox homeostasis, is found dysregulated in GDM, thereby affecting placental angiogenesis [51]
Studies have found that exposure to elevated glucose levels significantly augmented oxidant production in trophoblasts, culminating in ferroptosis in human trophoblast cells
Berdenis Van Berlekom A, Muflihah CH, Snijders GJLJ, MacGillavry HD, Middeldorp J, Hol EM, et al
She majored in chemistry at Harvard University, and as an undergraduate studied molecular recognition in the laboratory of Gregory Verdine
Furthermore, melanin exists in two forms: eumelanin (which is dark and brown) and pheomelanin (which is yellow and red)
Blood glucose and fasting insulin levels were markedly elevated in HFD-fed mice and showed a higher HOMA insulin resistance index (Fig