Titration experiments were performed for Rheb WT, Rheb K151Q and Rheb K151R with GppNHp at five different ratio (1:0.25, 1:0.5, 1:1, 1:2 and 1:5)
In vivo preclinical models investigating musculoskeletal injury, dermal repair, gastrointestinal integrity, or inflammatory conditions through pathways involving angiogenesis, ECM turnover, and cellular protection
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The findings are intended to advance mechanistic understanding of endocrine signaling architecture and regulatory complexity, rather than to inform therapeutic use or clinical application
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