glutathione reductase uses nadph to reduce gssg to gsh reaction Disulfide - an overview Analysis of GSH and GSSG

On the basis of the aforementioned information, one may hypothesize that glutathionylation of DNA-repair proteins may fail to repair or misrepair the DNA lesions induced by radiation in BSO-treated cells

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PPH00333B for c-FLIP

Upon cellular stress, characteristic of ASD [158], ROS production and elevated intracellular Ca 2+ concentration trigger mPTP opening leading to mitochondrial membrane permeabilization (MMP) [181], initiating apoptosis and necrosis [269], and regulating the activity of autophagy [270, 271]

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