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Al-Lawati JA, Mohammed AJ, Al-Hinai HQ, Jousilahti P

After the study, these rabbits were assessed morphologically and histopathologically to determine the degree of cartilage degeneration

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roughly 50-98 % of an administered dose is renally excreted unmetabolized, underscoring the low intrinsic toxicity

This effect is believed to be due to IGF-1 suppression of insulin secretion, which leads to augmented lipolysis in adipose tissue and promotion of FFA use by muscle