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Journal of Orthopaedic Research

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Furthermore, when we examined the expression of genes encoding enzymes that act as metabolic gatekeepers in CD4 + T cells, we found a BHD-induced upregulation of Cpt1 (fatty acid oxidation), Got1 (amino acid metabolism), Ndufs8 (OXPHOS), Sdha , Sdhb , Sdhc (TCA cycle) and Txnrd1 (redox balance) (Fig

Structural analysis of the wild-type HsaGST A2-2 and HsaGST A3-3 shows that the steroid substrate is not binding to HsaGST A2-2 in an orientation compatible with ketosteroid isomerase activity, apparently explaining the different activities of the two enzymes (Tars et al., 2010)