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Long Journal of the American Chemical Society 1960 82 (4), 795-798 DOI : 10.1021/ja01489a008 This is the paper giving the pK a of water as 15.7 whose methods are criticized in the above articles

These methods serve research applications where precise potency determination is essential

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19 is a graph illustrating the effect of half-dose Protandim-II on plasma TBARS in humans subjects

The target protein can then be obtained by changing the elution conditions