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discovered that lactate from melanoma stimulates sterol regulatory element-binding protein 2 (SREBP2) in tumor DCs, leading to the transformation of conventional DCs into cluster of differentiation 63 (CD63)+ mature regulatory DCs (mregDCs) through homeostatic or tolerogenic maturation

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Additionally, high levels of glutamate can affect ROS metabolism in T cells by disrupting the function of the Xc^- transporter, which is essential for cysteine uptake and GSH synthesis [179]

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Gastroenterology 139 , 19421951 (2010)