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Heinemeier KM, Mackey AL, Doessing S, Hansen M, Bayer ML, Nielsen RH, et al

Although it was originally developed to suppress oncogenic transcription factors such as androgen receptor and MYC, recent findings have shown that CCS1477 also effectively represses NRF2-dependent cytoprotective gene expression, which plays a central role in chemoresistance and immune evasion in KEAP1-mutant cancers [323]

Quintanilha for helping generate some images

doi: 10.1073/pnas.89.6.2399 149 ZhangW.XiaoD.MaoQ.XiaH

FOXO4-DRI is a senolytic peptide a D-retro-inverso peptide engineered to selectively eliminate senescent "zombie" cells that accumulate with age and secrete inflammatory factors (the senescence-associated secretory phenotype, or SASP)