A third widely-cited paper (McCoy 2013, PMID 23055539) the source of the often-repeated "seven orders of magnitude more potent than BDNF" line carries a 2021 Expression of Concern
NAD + also regulates non-redox NAD + -dependent enzymes such as poly-ADP-ribose-polymerases (PARPs) and sirtuins 519
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Int J Biol Sci 13:815827 Tikhanovich I, Cox J, Weinman SA (2013) Forkhead box class O transcription factors in liver function and disease
Precision timing approach: DSIP has a very short plasma half-life, estimated around 7-15 minutes in some studies
It primarily exerts these effects through its interactions with enzymes required to create clotting factors and those that inhibit plasminogen