When consuming more than 800-1000mcg (inorganic selenium) per day for long periods, you may experience symptoms of selenium toxicity, such as numbness in the hands and feet, a metallic taste in your mouth and bad breath
Why am I losing weight on creatine
When MTX enters a cell through carriers referred to as human-reduced folate carriers (SLC19A1), polyglutamate synthetase attaches glutamate residues to the -carboxylate group of MTX, converting it into methotrexate polyglutamates (MTX-PGs)
The drug gets activated in the scalp when it's converted to minoxidil sulfate by the enzyme sulfotransferase (SULT1A1) in the follicle
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Additionally, CD147-targeting therapies, including anti-CD147 antibodies, modulate MCT1/4 surface expression, although off-target effects remain a concern (184)
