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Health benefits and anti-inflammatory activities have been attributed to the activity of tocochromanol catabolites, especially the 13'-COOH catabolite since it inhibits 5-lipoxygenase a key enzyme in the biosynthesis of leukotrienes from arachidonic acid

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Finally, the in vivo efficacy of these small-molecule-derived HBs was demonstrated through transplantation into DMN-induced acute liver failure NSI mice