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[14] [15] For those with specific athletic goals, sports nutrition consensus statements (including those from the International Olympic Committee and the British Dietetic Association's Sports Dietitians group) suggest protein intakes in the range of 1.62.2 g per kg of body weight per day to support muscle retention during periods of energy restriction

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The peptide is also reported to remain stable in human gastric juice for over 24 hours, which is unusual and theorized to underpin oral activity in animals

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The lack of a well-defined primary receptor for DSIP has hampered mechanistic research if such a receptor exists, it has not been convincingly identified and cloned, leading some researchers to propose that DSIP may work through non-receptor-mediated mechanisms or through promiscuous interactions with multiple receptor systems