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If you want to try switching to black coffee, choose fresh, high-quality coffee

2004 Nov-Dec;22(6):343-52

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Concurrently, a significant increase in NADH/NAD + ratio ( P = 0.0002) was observed (Figure 6C), suggesting that the observed metabolic disruptions were a result of oxidative stress, potentially as a compensatory mechanism to sustain energy production and redox homeostasis in the absence of GR

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Hassani, N., Jafari-Gharabaghlou, D., Dadashpour, M