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To confirm these results, the authors proposed to engineer the CHO host cell line to eliminate the endogenous expression of LPLA2 and to repeat the formulation experiments to determine whether they are stabilised, i.e., reduced polysorbate hydrolysis, using the LPLA2 knockout approach (Hall et al., 2016)

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(2) What additional adverse outcomes might result from inflammation provoked by adjuvant-containing vaccinations