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Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas

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The gut microbiota modulates these pathways: an appropriate balance of pro-inflammatory cytokines (TNF-, IL-1, IL-6) and anti-inflammatory cytokines (IL-10, TGF-) is essential for resolution of injury 12

Supporting this notion, Ricci and colleagues (2003) reported that the proteolytic activity of caspases caused mitochondrial outer membrane permeabilization, altering complexes I and II activity in the electron transport chain, leading to a loss of the proton gradient, changes in transmembrane potential, mitochondrial ROS overproduction, and subsequent apoptosis 41

Zheng, N.-N