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Preferred for patients with MTHFR mutations (which are common in the general population) and for patients who want the most directly usable form

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Vitamin B12 plays a role in supporting neurological function and cognitive processes

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While oral bioavailability is lower than subcutaneous administration, these studies established that even high oral doses maintained excellent safety profiles, though higher doses (54 mg) were associated with increased gastrointestinal discomfort