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Other reasons include: bariatric surgery or bowel resection, age, those with GI diseases such as Crohns and Celiac, people taking Metformin to control their blood sugar and thos taking proton pump inhibitors (Prevacid, Prilosec, etc) for chronic heartburn

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Therefore, the two major effects that are enhanced by IGF-1 are FFA use by muscle and GH suppression

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It is studied for its selective action on lipolytic pathways without activating the IGF-1 receptor