In addition, activation of Nrf2 leads to the synthesis of HO-1 and the formation of a large number of bioactive metabolites, which may control the activation and metabolism of joint cells and play a regulatory role in joint destruction (220)
Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis
Cuccaro R, Masini M, Malanho Silva J, Camponeschi F, Banci L
First, osteoarthritis is one of the most common chronic pain conditions globally and is directly worsened by excess body weight
One of the most significant issues is their high inter-donor variability, which significantly impairs data reproducibility and limits further bioinformatic data analysis
Zhou TJ, Zhang MM, Liu DM, Huang LL, Yu HQ, Wang Y, et al