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J Biol Chem 294(28):1080710818

215,216 Interestingly, PS1 overexpression reduces p53 activity, which forms a negative feedback mechanism to regulate p53 activity

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Studies using adult human peripheral T cells demonstrated that glutamate at low concentrations ( 1 mM), however, this effect reversed, indicating that glutamate tends to have immunosuppressive properties at higher concentrations (176, 178)

Because tirzepatide activates a broader receptor footprint, it is studied as a model for combinatorial incretin pharmacology rather than single-pathway agonism