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Hemolytic anemia after methylene blue therapy for aniline-induced methemoglobinemia

The Journal of Allergy and Clinical Immunology: In Practice , 6 (1), 183-189

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To date, clinical trials with inosine have been published and the results have been inconsistent [165167]

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As a mitigation strategy, if the test for period effect post unblinding was significant, then the statistical model for the primary outcome had to be recomputed only on the data from the first period of the trial (where period effect is taken out)as recommended by clinical practice (3537)