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The JAK/STAT signaling pathway, as the main target for inhibiting the action of a variety of cytokines (221), is involved in the signal transduction of many key cytokines for the pathogenesis of RA and has been considered as a potential target for the treatment of RA (222)

Although rare under physiological conditions, their numbers increase with age and are remarkably elevated in neurodegenerative disorders (Bisht et al., 2016)

Therefore, they may be used for conditions such as: Age spots Melasma Freckles Hyperpigmentation caused by eczema or psoriasis 3.2