3 Estrogen signaling in skin Estrogen actions are mediated through canonical nuclear and/or non-canonical membrane-initiated steroid signaling ( ++ , cAMP, or protein kinase cascades) that regulate downstream transcription and epigenetic factors (Figure 3), although this has not been directly investigated, and data regarding the role and expression of ER in skin cells and during wound healing are inconsistent (Verdier-Sevrain et al., 2004)
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Koeth RA, Wang Z, Levison BS, Buffa JA, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL: Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
It has been extensively documented that persistent intestinal mucosal inflammation and tissue damage constitute the core pathological manifestations of IBD, which are driven by dysfunctions in multiple physiological regulatory systems: At the immunological level, aberrant activation of both innate and adaptive immune responses, in conjunction with cytokine network dysregulation, has been shown to directly drive the initiation and amplification of inflammatory responses [18,19,20]
