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Further development of TGR-based therapeutic approaches is impeded by the lack of non-covalent small molecule inhibitors of TGR, a well-known and general problem for all the members of the high molecular weight, Sec-containing TrxR subfamily that are considered attractive and unexploited drug targets for several human diseases 21,22

The shear stress, representing shear force per unit area, is particularly elevated near the vessel wall with values ranging from 1 to 4 dyn/cm 2 in veins, and 430 dyn/cm 2 in arteries [219]

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Obsessive-compulsive disorder, insulin signaling and diabetesa novel form of physical health comorbidity: the sweet compulsive brain