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Free Radic Biol Med 25:287297 Lopez-Lluch G, Hunt N, Jones B, Zhu M, Jamieson H, Hilmer S, Cascajo MV, Allard J, Ingram DK, Navas P, de Cabo R (2006) Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency
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In a hypoxic and glucose-deprived TME, The metabolism of Gln is essential for tumor cells to survive and multiply ( Additionally, metabolomic analyses reveal low levels of Gln and elevated levels of glutamate in TNBC, suggesting that TNBC is more dependent on Gln and more sensitive to therapies targeting Gln breakdown compared to other breast cancer subtypes ( The role of Gln is critical in both the proliferation and metastasis of cancer cells
10.1530/REP-22-0152 126 RutkowskiM.GrzegorczykK
The capsule, especially if its an enteric-coated or delayed-release formulation, is crucial for protecting the delicate peptide from the highly acidic environment of the stomach
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