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An RCT that investigated the effect of 6 g/d PUFA supplementation during 4 months on patients with migraine, found that omega-3 fatty acids did not have any significant influence on mean duration and intensity of the migraine attacks, and rescue medication use

Nevertheless, these studies collectively suggest potential benefits of lipoic acid for chemotherapy-induced neuropathy at daily doses ranging from 600 mg to 1,800 mg, though the larger trial underscores the need for well-designed regimens and careful patient adherence to confirm efficacy over extended treatment courses

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