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In two trials employing 1000 g/day oral vitamin B 12 , there was no clinically relevant difference in vitamin B 12 levels when compared with IM vitamin B 12

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Earlier shorter trials reported small statistically significant differences but the effect sizes were modest

(PubMed) Ravaglia G, Forti P, Maioli F, et al

Supplementing with vitamin B12 lowers homocysteine levels and may improve mood, particularly in response to stress