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One of the biologically most active carotenoids against oxidative damage, lycopene, contains 11 conjugated double bonds and has been reported to have anticancer activities via regulation of oxidative enzymes such as cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), inhibitory effect on tumor growth and progression, triggering apoptosis, modulation of proteins involved in cell cycle regulation, reduction of the incidence of breast, liver, pancreatic and other cancers (Tang et al

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Roth JA, Grammer SF, Swisher SG , Nemunaitis J, Merritt J, Meyn RE Jr

Long-term human experiments with PQQ have not revealed complications, making it food-grade