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But so far, there havent been randomized, controlled trials in humans, the gold standard for determining whether a treatment actually works and is safe

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A population- based study using the Hungarian Case- Control Surveillance of Congenital Abnormalities database did not show a significant increase in the prevalence of congenital abnormalities in the children of women treated with sulfasalazine

It also reduced the expressions of inflammation regulating enzymes like MMP-1, MMP-9 and MMP-13 (matrix metalloproteinase), a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS-4 & 5)

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