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You are at risk for B12 deficiency if you: Are a vegetarian Are a vegan Have chronic gastritis Have had previous surgery on your stomach Have any chronic bowel conditions, such as Chrons disease or colitis You take certain medications, such as proton pump inhibitors (PPI's) - a medicine sometimes used to treat heartburn and indigestion What are the signs and symptoms associated with a B12 deficiency

Meth-Cohn, Eds., Comprehensive Natural Products Chemistry

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Because B12 is water-soluble, excess amounts are naturally excreted by the body, making toxicity extremely rare