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doi: 10.1038/s41419-019-1965-7 47

[DOI] [PubMed] [Google Scholar] Cox et al

doi: 10.1155/2016/5698931 251 PaulBDLemleMDKomaroffALSnyderSH

doi: 10.3390/ijms22147582 177

Despite these challenges, IN delivery is predominantly used for emergency medicine in clinical settings due to its rapid onset, ease of administration, and ability to bypass hepatic first-pass metabolism

Animal numbers were chosen with consideration of ethical requirements and the 3Rs principle (replacement, reduction, refinement) to balance statistical sensitivity with minimizing animal use 18