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Nutrients, 11 (10), 2362

Pat it in gently rather than rubbing

Unlike small-molecule drugs that are chemically stable across a wide range of conditions, peptides can hydrolyze, oxidize, and aggregate under conditions most people would consider normal, such as room temperature, moderate humidity, or standard kitchen lighting

Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or treatment.

Sources: Hangovers - Symptoms and causes | The Mayo Clinic Drug Bioavailability - StatPearls | NCBI Bookshelf

Give a routine or supplement for at least 1014 nights if it is safe for you