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Interim analysis of 50% of the patients after 6 months follow-up indicated a greater reduction in low back pain and an improvement in function in patients receiving 6*10 6 immunoselected and culture-expanded MSCs compared with control patients

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Standard Protocol (Weeks 5-12) Daily Dose : 400 mcg subcutaneous injection Timing : Morning, fasted state preferred Frequency : Once daily Duration : 8-12 weeks continuous use The 400 mcg dose represents the optimal balance between efficacy and tolerability for most individuals

The trial was registered at irct.ir website (IRCT20120718010333N5)